Linking pathways in colorectal cancer

被引：16

作者：

van den Brink, GR ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Expt Internal Med, NL-1105 AZ Amsterdam, Netherlands

来源：

NATURE GENETICS | 2004年 / 36卷 / 10期

关键词：

D O I：

10.1038/ng1004-1038

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Studies of inherited cancer syndromes have implicated numerous signaling pathways in colorectal carcinogenesis, but the relationship between these signaling pathways remains poorly understood. Now, a new mouse model of juvenile polyposis syndrome identifies a molecular mechanism for clonal epithelial cell expansion and links several pathways with an established role in polyposis.

引用

页码：1038 / 1039

页数：2

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