Progressive supranuclear gaze palsy is in linkage disequilibrium with the τ and not the α-synuclein gene

被引：89

作者：

Higgins, JJ

Litvan, I

Pho, LT

Li, W

Nee, LE

机构：

[1] NINDS, Med Neurol Branch, Clin Neurogenet Unit, NIH, Bethesda, MD 20892 USA

[2] NINDS, Neuroepidemiol Branch, NIH, Bethesda, MD 20892 USA

[3] Rockefeller Univ, Lab Stat Genet, New York, NY 10021 USA

来源：

NEUROLOGY | 1998年 / 50卷 / 01期

关键词：

D O I：

10.1212/WNL.50.1.270

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied two candidate genes, tau (tau) and alpha-synuclein (SNCA), for evidence of linkage disequilibrium on a group of unrelated individuals with progressive supranuclear palsy (PSP) and a group of age-matched control subjects. The tau a(1) allele and the tau a(1)a(1) genotype were overrepresented in individuals with PSP and the tau polymorphism was in linkage disequilibrium with the PSP disease locus when a recessive inheritance model was employed. We also report a lack of evidence to support linkage disequilibrium between PSP and the SNCA candidate Parkinson's disease gene on chromosome 4q21-q23.

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页码：270 / 273

页数：4

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