Towards a splicing code

被引：62

作者：

Fu, XD ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Celluar & Mol Med, La Jolla, CA 92093 USA

来源：

CELL | 2004年 / 119卷 / 06期

关键词：

D O I：

10.1016/j.cell.2004.11.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A combination of experimental and bioinformatics approaches leads Burge and colleagues (Wang et al., 2004 [this issue of Cell]) to a global view of how an RNA segment may be selected or avoided in mature mRNAs due to biased distributions of exonic enhancers and silencers, a process vital for genome evolution, developmental control, and disease onset.

引用

页码：736 / 738

页数：3

共 7 条

[1] EXON RECOGNITION IN VERTEBRATE SPLICING [J].

BERGET, SM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (06) :2411-2414

[2] Predictive identification of exonic splicing enhancers in human genes [J].

Fairbrother, WG ;

Yeh, RF ;

Sharp, PA ;

Burge, CB .

SCIENCE, 2002, 297 (5583) :1007-1013

[3] Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins [J].

Liu, HX ;

Zhang, M ;

Krainer, AR .

GENES & DEVELOPMENT, 1998, 12 (13) :1998-2012

[4] Multiple splicing defects in an intronic false exon [J].

Sun, HZ ;

Chasin, LA .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (17) :6414-6425

[5] In vitro selection of functional nucleic acids [J].

Wilson, DS ;

Szostak, JW .

ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :611-647

[6] Identification of protein coding regions in the human genome by quadratic discriminant analysis [J].

Zhang, MQ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (02) :565-568

[7] Computational definition of sequence motifs governing constitutive exon splicing [J].

Zhang, XHF ;

Chasin, LA .

GENES & DEVELOPMENT, 2004, 18 (11) :1241-1250

← 1 →