Effect of infant immunisation with meningococcus serogroup C-CRM197 conjugate vaccine on diphtheria immunity and reactogenicity in pre-school aged children

被引：11

作者：

McVernon, J

MacLennan, J

Clutterbuck, E

Buttery, J

Moxon, ER

机构：

[1] John Radcliffe Hosp, Dept Paediat, Oxford Vaccine Grp, Headington OX20 1XN, Oxon, England

[2] Univ Oxford, Dept Zool, Oxford OX1 3PS, Oxon, England

[3] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

来源：

VACCINE | 2003年 / 21卷 / 19-20期

关键词：

diphtheria; meningococcal vaccines; immunisation schedule;

D O I：

10.1016/S0264-410X(03)00058-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The majority of Men C conjugate vaccines given in the UK use CRM197, a mutant diphtheria toxoid, as their protein carrier. We studied the effects of prior immunisation with Men C-CRM197 conjugate vaccine on immunity to diphtheria in 193 children before and after a booster dose of Men C at 4 years. Baseline diphtheria antibodies were higher in children given four previous doses of Men C (P < 0.0001) and tended to be higher following boosting in those who had received three or four doses. This enhanced immunity was not associated with increased reactogenicity. (C) 2003 Elsevier Science Ltd. All rights reserved.

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收藏

页码：2573 / 2579

页数：7

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