Immune suppression and skin cancer development: regulation by NKT cells

被引：247

作者：

Moodycliffe, AM

Nghiem, D

Clydesdale, G

Ullrich, SE

机构：

[1] Grad Sch Biomed Sci, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

NATURE IMMUNOLOGY | 2000年 / 1卷 / 06期

关键词：

D O I：

10.1038/82782

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo.

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收藏

页码：521 / 525

页数：5

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