Recurrence of lymphangioleiomyomatosis after single lung transplantation:: New insights into pathogenesis

被引：82

作者：

Bittmann, I

Rolf, B

Amann, G

Löhrs, U

机构：

[1] Univ Munich, Inst Pathol, D-80337 Munich, Germany

[2] Univ Munich, Inst Forens Med, D-80337 Munich, Germany

来源：

HUMAN PATHOLOGY | 2003年 / 34卷 / 01期

关键词：

lung transplantation; lymphangioleiomyomatosis; recurrence; nonisotopic in situ hybridization; short-tandem repeat loci analysis;

D O I：

10.1053/hupa.2003.50

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Lymphangioleiomyomatosis (LAM) is a rare disease found primarily in white women of childbearing age. The present study describes a case of recurrent LAM after single lung transplantation. Double-staining nonisotopic in situ hybridization, immunohistochemistry, and short tandem repeat loci analysis demonstrated that the recurrent LAM lesions originated from the recipient. The data strongly support that metastatic spread of LAM cells or migration of progenitor cells plays an important role in the pathogenesis of LAM.

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页码：95 / 98

页数：4

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