Function of bone morphogenetic protein signaling during mouse development

被引：69

作者：

Mishina, Y ^{[1
]}

机构：

[1] NIEHS, Mol Dev Biol Sect, Reprod & Dev Toxicol Lab, Res Triangle Pk, NC 27709 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2003年 / 8卷

关键词：

BMP; embryogenesis; patterning; gastrulation; receptor; kinase; skeletalgenesis; review;

D O I：

10.2741/1097

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone morphogenetic proteins (BMPs) play pleiotropic roles during development and after birth in many different organisms. BMPs are members of TGF-beta superfamily. There are more than 20 members with three type II receptors and three type I receptors. Genetic approaches using the mouse as a model system revealed many of the functions of BMPs. Particularly, results obtained through loss-of-function analyses of BMP ligands and their receptors are reviewed in this article.

引用

页码：D855 / D869

页数：15

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