Synthetic oligonucleotides: Useful molecules? A review

被引：11

作者：

Calogero, A ^{[1
]}

Hospers, GAP ^{[1
]}

Mulder, NH ^{[1
]}

机构：

[1] Univ Groningen Hosp, Dept Int Hlth, Div Med Oncol, NL-9700 RB Groningen, Netherlands

来源：

PHARMACY WORLD & SCIENCE | 1997年 / 19卷 / 06期

关键词：

antisense oligonucleotides; antisense strategy; antigene strategy; ribozymes; oncogenes;

D O I：

10.1023/A:1008699515124

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Specific inhibition of mammalian genes is possible through the use of antisense oligonucleotides (AS ODNs) or ribozymes. These strategies have led to a better understanding of several cellular and molecular mechanisms, among which cancer development. Recently, these strategies have been applied also for therapeutical purposes in diseases such as AIDS and cancer. In some of these therapeutical trials the antisense strategy is combined with gene transfer technology: the AS ODN or the ribozyme are expressed within the cell by the use of adenoviral or retroviral vectors. However, many difficulties have still to be overcome before ODNs and ribozymes can be used routinely in the clinic.

引用

页码：264 / 268

页数：5

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