Dichloromethane activation.: Direct methylenation of ketones and aldehydes with CH2Cl2 promoted by Mg/TiCl4/THF

被引：82

作者：

Yan, TH ^{[1
]}

Tsai, CC ^{[1
]}

Chien, CT ^{[1
]}

Cho, CC ^{[1
]}

Huang, PC ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Chem, Taichung 400, Taiwan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 26期

关键词：

D O I：

10.1021/ol0478887

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This Mg-TiCl4-promoted CH2-transfer reaction of CH2Cl2 represents an extremely simple, practical, and efficient methylenation of a variety of ketones and aldehydes, especially in enolizable or sterically hindered ketones such as 2,2-dimethylcyclohexanone, camphor, and fenchone.

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收藏

页码：4961 / 4963

页数：3

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