Molecular Detection of Colorectal Neoplasia

被引：119

作者：

Ahlquist, David A. ^{[1
]}

机构：

[1] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

来源：

GASTROENTEROLOGY | 2010年 / 138卷 / 06期

关键词：

Colorectal Cancer Screening; Stool DNA; Molecular Tests; FECAL-OCCULT-BLOOD; HUMAN COLON-CANCER; ABERRANT CRYPT FOCI; CIRCULATING TUMOR-CELLS; CPG ISLAND METHYLATION; STOOL DNA; ADENOMATOUS POLYPS; PERIPHERAL-BLOOD; AMERICAN-COLLEGE; SCREEN-DETECTION;

D O I：

10.1053/j.gastro.2010.01.055

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and user-friendliness. These approaches are based on the sensitive assay of molecular markers in stool, blood, and urine samples. New methods, especially next generation stool-based tests, have been shown to detect both colorectal cancers and precancerous lesions with high accuracy. Validation of these technologies in average-risk populations are needed to establish their role for general colorectal cancer screening. This review addresses the biological rationale, technical advances, recent clinical performance data, and remaining issues with molecular screening for colorectal cancer.

引用

页码：2127 / 2139

页数：13

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