Helicobacter pylori gastritis and gastric physiology

被引：93

作者：

McColl, KEL ^{[1
]}

El-Omar, E

Gillen, D

机构：

[1] Western Infirm & Associated Hosp, Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland

[2] Univ Aberdeen, Dept Med & Therapeut, Aberdeen, Scotland

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2000年 / 29卷 / 03期

关键词：

D O I：

10.1016/S0889-8553(05)70138-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

It is now recognized that Helicobacter pylori infection exerts profound and diverse effects on gastric acid secretory function and that the alterations in acid secretion depend on the pattern of gastritis caused by the infection. In patients with an antral predominant nonatrophic gastritis, there is acid hypersecretion leading to duodenal ulcer disease. In patients with an atrophic pangastritis, there is markedly reduced acid secretion and increased risk for gastric cancer. It is now recognized that acid secretion also modifies H. pylori gastritis and a person's premorbid acid secretory status may be an important factor in determining the pattern of gastritis that an individual develops. This two-way interaction between H. pylori gastritis and gastric acid secretion is important in understanding the role of H. pylori infection in the response to proton-pump inhibitor therapy: It explains the more profound control of gastric acid secretion in H. pylori-positive patients and why rebound acid hypersecretion is confined to H. pylori-negative subjects.

引用

页码：687 / +

页数：18

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