New hydrolysis-dependent thermosensitive polymer for an injectable degradable system

被引：51

作者：

Cui, Zhanwu ^{[1
]}

Lee, Bae Hoon ^{[1
]}

Vernon, Brent L. ^{[1
]}

机构：

[1] Arizona State Univ, Harrington Dept Bioengn, Ctr Intervent Biomat, Tempe, AZ 85287 USA

来源：

BIOMACROMOLECULES | 2007年 / 8卷 / 04期

关键词：

D O I：

10.1021/bm061045g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel, bioerodible, thermosensitive poly(NIPAAm-co-dimethyl-gamma-butyrolactone acrylate), with a hydrolysis-dependent thermosensitivity, was synthesized by radical polymerization with a varying dimethyl-gamma-butyrolactone acrylate (DBA) content, and the properties of the copolymers were characterized using differential scanning calorimetry, gel permeation chromatography in conjunction with static light scattering, Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and acid titration. The lower critical solution temperature of the copolymers decreases with increasing DBA content, but then increases after ring-opening hydrolysis of the DBA side group. FTIR and NMR spectra showed the copolymerization of these two monomers and the hydrolysis-dependent ring-opening of the DBA side group. It was also found that there are no low-molecular-weight byproducts but rather dissolution of the polymer chains at 37 degrees C during the time frame of application. Models of the kinetics suggest that the hydrolysis reaction is self-catalytic due to an increase in hydrophilicity and charge, and thus accessible water concentration, caused by ring-opening of the DBA.

引用

页码：1280 / 1286

页数：7

共 31 条

[11]

2-7

[12] Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(D,L-lactide-co-glycolide) with varying compositions [J].

Liu, SQ ;

Tong, YW ;

Yang, YY .

BIOMATERIALS, 2005, 26 (24) :5064-5074

[13]

Montgomery D., 2001, DESIGN ANAL EXPT, P684

[14] Degradation mechanism and kinetics of thermosensitive polyacrylamides containing lactic acid side chains [J].

Neradovic, D ;

van Steenbergen, MJ ;

Vansteelant, L ;

Meijer, YJ ;

van Nostrum, CF ;

Hennink, WE .

MACROMOLECULES, 2003, 36 (20) :7491-7498

[15] Thermoresponsive polymeric micelles with controlled instability based on hydrolytically sensitive N-isopropylacrylamide copolymers [J].

Neradovic, D ;

van Nostrum, CF ;

Hennink, WE .

MACROMOLECULES, 2001, 34 (22) :7589-7591

[16]

Neradovic D, 2001, J CONTROL RELEASE, V72, P252

[17]

Neradovic D, 1999, MACROMOL RAPID COMM, V20, P577, DOI 10.1002/(SICI)1521-3927(19991101)20:11<577::AID-MARC577>3.0.CO

[18]

2-D

[19] THERMAL-ANALYSIS OF THE VOLUME PHASE-TRANSITION WITH N-ISOPROPYLACRYLAMIDE GELS [J].

OTAKE, K ;

INOMATA, H ;

KONNO, M ;

SAITO, S .

MACROMOLECULES, 1990, 23 (01) :283-289

[20] A NEW MODEL FOR THE THERMALLY INDUCED VOLUME PHASE-TRANSITION OF GELS [J].

OTAKE, K ;

INOMATA, H ;

KONNO, M ;

SAITO, S .

JOURNAL OF CHEMICAL PHYSICS, 1989, 91 (02) :1345-1350

← 1 2 3 4 →