Carbon metabolism of intracellular bacterial pathogens and possible links to virulence

被引：306

作者：

Eisenreich, Wolfgang ^{[4
]}

Dandekar, Thomas ^{[3
]}

Heesemann, Juergen ^{[1
]}

Goebel, Werner ^{[1
,2
]}

机构：

[1] Univ Munich, Max von Pettenkofer Inst, D-80090 Munich, Germany

[2] Univ Wurzburg, Bioctr Microbiol, D-97074 Wurzburg, Germany

[3] Univ Wurzburg, Bioctr Bioinformat, D-97074 Wurzburg, Germany

[4] Tech Univ Munich, Lehrstuhl Biochem, D-85747 Garching, Germany

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 06期

关键词：

ENTERICA SEROVAR TYPHIMURIUM; III SECRETION SYSTEM; SHIGELLA-FLEXNERI; 2A; CHAIN FATTY-ACIDS; MYCOBACTERIUM-TUBERCULOSIS; LISTERIA-MONOCYTOGENES; GENE-EXPRESSION; TRANSCRIPTIONAL ADAPTATION; SALMONELLA-TYPHIMURIUM; PHOSPHOTRANSFERASE SYSTEM;

D O I：

10.1038/nrmicro2351

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

New technologies such as high-throughput methods and C-13-isotopologue-profiling analysis are beginning to provide us with insight into the in vivo metabolism of microorganisms, especially in the host cell compartments that are colonized by intracellular bacterial pathogens. In this Review, we discuss the recent progress made in determining the major carbon sources and metabolic pathways used by model intracellular bacterial pathogens that replicate either in the cytosol or in vacuoles of infected host cells. Furthermore, we highlight the possible links between intracellular carbon metabolism and the expression of virulence genes.

引用

页码：401 / 412

页数：12

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