CD23/FcεRII: molecular multi-tasking

被引：139

作者：

Acharya, M. ^{[1
]}

Borland, G. ^{[1
]}

Edkins, A. L. ^{[1
]}

MacLellan, L. M. ^{[1
]}

Matheson, J.

Ozanne, B. W. ^{[2
]}

Cushley, W. ^{[1
]}

机构：

[1] Univ Glasgow, Fac Biomed & Life Sci, Div Mol & Cellular Biol, Glasgow G12 8QQ, Lanark, Scotland

[2] CR UK Beatson Inst, Glasgow, Lanark, Scotland

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2010年 / 162卷 / 01期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

CD23; cytokines; IgE; immunoregulation; integrins; CHRONIC LYMPHOCYTIC-LEUKEMIA; IMMUNOGLOBULIN-E RECEPTOR; AFFINITY IGE RECEPTOR; REGULATES MONOCYTE ACTIVATION; ACUTE RESPIRATORY SYNDROME; PRIMARY SJOGRENS-SYNDROME; HUMAN B-LYMPHOCYTES; SOLUBLE CD23 LEVELS; EPSTEIN-BARR-VIRUS; T-CELL RESPONSES;

D O I：

10.1111/j.1365-2249.2010.04210.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

P>CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. Translational studies of CD23 underline its credibility as a target for therapeutic intervention strategies and illustrate its involvement in mediating therapeutic effects of antibodies directed at other targets.

引用

页码：12 / 23

页数：12

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