5-HT1A responsivity in patients with panic disorder before and after treatment with aerobic exercise, clomipramine or placebo

被引:28
作者
Broocks, A
Meyer, T
Opitz, M
Bartmann, U
Hillmer-Vogel, U
George, A
Pekrun, G
Wedekind, D
Rüther, E
Bandelow, B
机构
[1] Med Univ Lubeck, Dept Psychiat & Psychotherapy, D-23538 Lubeck, Germany
[2] Univ Wurzburg, Dept Neurol, D-79080 Wurzburg, Germany
[3] Univ Gottingen, Dept Sports Med, D-37075 Gottingen, Germany
[4] Univ Gottingen, Dept Psychiat & Psychotherapy, D-37075 Gottingen, Germany
[5] Inst Sports & Prevent Med, D-66041 Saarbrucken, Germany
关键词
panic disorder; 5-HT1A receptors; ipsapirone; aerobic exercise; clomipramine;
D O I
10.1016/S0924-977X(02)00177-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Blunted neuroendocrine and physiological responses to the selective 5-HT1A receptor agonist, ipsapirone, have been observed in patients with panic disorder and/or agoraphobia (PDA). In order to examine whether this hyporesponsiveness to ipsapirone is modified by pharmacological or non-pharmacological therapeutic interventions, challenges with an oral dose of ipsapirone (0.3 mg/kg) and placebo were performed in patients with PDA before and after 10 weeks of treatment with clomipramine, aerobic exercise and placebo. Before treatment, administration of ipsapirone was followed by significant increases of cortisol, anxiety and other psychopathological symptoms in comparison to the placebo challenge. In addition, a significant decrease of body temperature was observed. After the 10-week treatment period, the psychological responses to ipsapirone were significantly reduced in the clornipramine and the exercise group. In contrast, there was a non-significant trend towards higher cortisol responses after clornipramine and exercise treatment. The hypothermic response to ipsapirone was significantly reduced by clornipramine treatment. In conclusion, our results demonstrate that effective treatment of panic disorder has divergent effects on the psychological, neuroendocrine and temperature responses to ipsapirone. (C) 2003 Elsevier Science B.V./ECNP All rights reserved.
引用
收藏
页码:153 / 164
页数:12
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