Regulation of translation initiation factors by signal transduction

被引：159

作者：

Kleijn, M ^{[1
]}

Scheper, GC ^{[1
]}

Voorma, HO ^{[1
]}

Thomas, AAM ^{[1
]}

机构：

[1] Univ Utrecht, Dept Mol Cell Biol, NL-3584 CH Utrecht, Netherlands

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1998年 / 253卷 / 03期

关键词：

signal transduction; translation initiation; eukaryotic initiation factor 4E; initiation-factor-4E-binding protein; eukaryotic initiation factor 2B; mitogen-activated protein kinase; FK506-binding protein rapamycin-associated protein; mammalian target of rapamycin; inositolphospholipid; 3-kinase;

D O I：

10.1046/j.1432-1327.1998.2530531.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of eukaryotic translation initiation is a process that requires collaboration between multiple proteins. The cap-binding factor eukaryotic initiation factor (eIF)4E, its binding protein 4E-BP1, and the guanine-nucleotide-exchange factor eIF2B play important roles in the regulation of the rate of protein synthesis. This review describes the regulation of the activity of these three proteins and the signal-transduction pathways involved therein.

引用

页码：531 / 544

页数：14

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