Angiotensin-converting enzyme DD genotype in patients with primary pulmonary hypertension: increased frequency and association with preserved haemodynamics

被引：54

作者：

Abraham, WT

Raynolds, MV

Badesch, DB

Wynne, KM

Groves, BM

Roden, RL

Robertson, AD

Lowes, BD

Zisman, LS

Voelkel, NF

Bristow, MR

Perryman, MB

机构：

[1] Univ Colorado, Sch Med, Dept Med, Div Cardiol, Denver, CO 80262 USA

[2] Univ Colorado, Sch Med, Dept Med, Div Pulm Med, Denver, CO 80262 USA

来源：

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | 2003年 / 4卷 / 01期

关键词：

angiotensin II; genetics; haemodynamics; polymerase chain reaction; pulmonary hypertension;

D O I：

10.3317/jraas.2003.003

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

A polymorphic marker within the angiotensin-converting enzyme (ACE) gene has been associated with circulating and tissue ACE activity and with a variety of forms of cardiovascular disease. Since angiotensin 11 (Ang 11) causes pulmonary vasoconstriction and vascular and myocardial remodelling, we postulated a role for the renin-angiotensin system and the ACE DD genotype in the pathophysiology of primary pulmonary hypertension (PPH) and in the right ventricular response to pressure overload in these patients.

引用

收藏

页码：27 / 30

页数：4

相关论文

共 19 条

[11] ANGIOTENSIN-CONVERTING ENZYME-DD GENOTYPE IN PATIENTS WITH ISCHEMIC OR IDIOPATHIC DILATED CARDIOMYOPATHY [J].

RAYNOLDS, MV ;

BRISTOW, MR ;

BUSH, EW ;

ABRAHAM, WT ;

LOWES, BD ;

ZISMAN, LS ;

TAFT, CS ;

PERRYMAN, MB .

LANCET, 1993, 342 (8879) :1073-1075

[12] PCR DETECTION OF THE INSERTION DELETION POLYMORPHISM OF THE HUMAN ANGIOTENSIN CONVERTING ENZYME GENE (DCP1) (DIPEPTIDYL CARBOXYPEPTIDASE-1) [J].

RIGAT, B ;

HUBERT, C ;

CORVOL, P ;

SOUBRIER, F .

NUCLEIC ACIDS RESEARCH, 1992, 20 (06) :1433-1433

[13] AN INSERTION DELETION POLYMORPHISM IN THE ANGIOTENSIN I-CONVERTING ENZYME GENE ACCOUNTING FOR HALF THE VARIANCE OF SERUM ENZYME LEVELS [J].

RIGAT, B ;

HUBERT, C ;

ALHENCGELAS, F ;

CAMBIEN, F ;

CORVOL, P ;

SOUBRIER, F .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (04) :1343-1346

[14]

SCHMENGLER K, 1983, HEMMUNG ANGIOTENSION

[15] ASSOCIATION BETWEEN A DELETION POLYMORPHISM OF THE ANGIOTENSIN-CONVERTING-ENZYME GENE AND LEFT-VENTRICULAR HYPERTROPHY [J].

SCHUNKERT, H ;

HENSE, HW ;

HOLMER, SR ;

STENDER, M ;

PERZ, S ;

KEIL, U ;

LORELL, BH ;

RIEGGER, GAJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (23) :1634-1638

[16]

TIRET L, 1992, AM J HUM GENET, V51, P197

[17] DELETION POLYMORPHISM IN ANGIOTENSIN-CONVERTING ENZYME GENE ASSOCIATED WITH PARENTAL HISTORY OF MYOCARDIAL-INFARCTION [J].

TIRET, L ;

KEE, F ;

POIRIER, O ;

NICAUD, V ;

LECERF, L ;

EVANS, A ;

CAMBOU, JP ;

ARVEILER, D ;

LUC, G ;

AMOUYEL, P ;

CAMBIEN, F .

LANCET, 1993, 341 (8851) :991-992

[18] DRUG EFFECTS ON THE PULMONARY CIRCULATION - AN OVERVIEW [J].

VOELKEL, NF .

SEMINARS IN RESPIRATORY MEDICINE, 1985, 7 (02) :141-146

[19] A MOLECULAR VARIANT OF ANGIOTENSINOGEN ASSOCIATED WITH PREECLAMPSIA [J].

WARD, K ;

HATA, A ;

JEUNEMAITRE, X ;

HELIN, C ;

NELSON, L ;

NAMIKAWA, C ;

FARRINGTON, PF ;

OGASAWARA, M ;

SUZUMORI, K ;

TOMODA, S ;

BERREBI, S ;

SASAKI, M ;

CORVOL, P ;

LIFTON, RP ;

LALOUEL, JM .

NATURE GENETICS, 1993, 4 (01) :59-61