Total synthesis of 26-hydroxy-epothilone B and related analogs via a macrolactonization based strategy

被引：45

作者：

Nicolaou, KC

Finlay, MRV

Ninkovic, S

Sarabia, F

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 25期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4020(98)00352-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chemical synthesis of a series of 26-substituted epothilones B is described. Fully protected 26-hydroxydesoxyepothilone B (7), prepared via the macrolactonization strategy, served as a common precursor to the designed epothilones described. The synthesized compounds were members of a large epothilone library whose biological screening led to the identification of a number of highly potent antitumor agents. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7127 / 7166

页数：40

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