The myosin coiled-coil is a truly elastic protein structure

被引:196
作者
Schwaiger, I
Sattler, C
Hostetter, DR
Rief, M
机构
[1] Lehrstuhl Angew Phys, D-80799 Munich, Germany
[2] Stanford Univ, Sch Med, Dept Biochem B400, Stanford, CA 94305 USA
关键词
D O I
10.1038/nmat776
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Coiled-coils occur in a variety of proteins involved in mechanical and structural tasks in the cell. Their mechanical properties are important in various contexts ranging from hair elasticity1 to synaptic fusion2. Beyond their importance in biology, coiled-coils have also attracted interest as programmable protein sequences for the design of novel hydrogels and materials3. We have studied the elastic properties of the myosin coiled-coil at the single molecule level. The coiled-coil undergoes a massive structural transition at forces between 20 and 25 pN where the coil extends to about 2.5 times its original length. Unlike all other proteins investigated mechanically so far, this transition is reversible on a timescale of less than a second, making the coiled-coil a truly elastic protein.
引用
收藏
页码:232 / 235
页数:4
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