Influence of host genetic variation on susceptibility to HIV type 1 infection

被引：116

作者：

Kaslow, RA

Dorak, T

Tang, J

机构：

[1] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[3] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 191卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1086/425269

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

For this review of genetic susceptibility to human immunodeficiency virus type 1 infection, far more information was available on factors involved in acquisition of the virus by an uninfected "recipient" than on propagation by the infected "donor." Genetic variation presumably alters transmission from an infected host primarily by regulating the replication of virus and the concentration of particles circulating in blood and mucosal secretions of the potential donor. Thus, the effects of host genetic variation on transmission are inextricably bound to the well-established and powerful effects on virus load at different stages of infection. Teasing apart the effects in both donors and recipients has been and will continue to be quite difficult.

引用

页码：S68 / S77

页数：10

共 138 条

[31] Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef [J].

Evans, DT ;

O'Connor, DH ;

Jing, PC ;

Dzuris, JL ;

Sidney, J ;

da Silva, J ;

Allen, TM ;

Horton, H ;

Venham, JE ;

Rudersdorf, RA ;

Vogel, T ;

Pauza, CD ;

Bontrop, RE ;

DeMars, R ;

Sette, A ;

Hughes, AL ;

Watkins, DI .

NATURE MEDICINE, 1999, 5 (11) :1270-1276

[32]

FABIO G, 1992, CLIN EXP IMMUNOL, V87, P20, DOI 10.1111/j.1365-2249.1992.tb06407.x

[33] Virologic and immunologic determinants of heterosexual transmission of human immunodeficiency virus type 1 in Africa [J].

Fideli, OS ;

Allen, SA ;

Musonda, R ;

Trask, S ;

Hahn, BH ;

Weiss, H ;

Mulenga, J ;

Kasolo, F ;

Vermund, SH ;

Aldrovandi, GM .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2001, 17 (10) :901-910

[34]

Galiani MD, 1999, CLIN EXP IMMUNOL, V115, P472

[35] Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS. [J].

Gao, XJ ;

Nelson, GW ;

Karacki, P ;

Martin, MP ;

Phair, J ;

Kaslow, R ;

Goedert, JJ ;

Buchbinder, S ;

Hoots, K ;

Vlahov, D ;

O'Brien, SJ ;

Carrington, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (22) :1668-1675

[36] Spontaneous and antigen-induced production of HIV-inhibitory β-chemokines are associated with AIDS-free status [J].

Garzino-Demo, A ;

Moss, RB ;

Margolick, JB ;

Cleghorn, F ;

Sill, A ;

Blattner, WA ;

Cocchi, F ;

Carlo, DJ ;

DeVico, AL ;

Gallo, RC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) :11986-11991

[37]

Geijtenbeek TBH, 2003, CURR TOP MICROBIOL, V276, P31

[38] Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes [J].

Gonzalez, E ;

Bamshad, M ;

Sato, N ;

Mummidi, S ;

Dhanda, R ;

Catano, G ;

Cabrera, S ;

McBride, M ;

Cao, XH ;

Merrill, G ;

O'Connell, P ;

Bowden, DW ;

Freedman, BI ;

Anderson, SA ;

Walter, EA ;

Evans, JS ;

Stephan, KT ;

Clark, RA ;

Tyagi, S ;

Ahuja, SS ;

Dolan, MJ ;

Ahuja, SK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) :12004-12009

[39] Global survey of genetic variation in CCR5, RANTES, and MIP-1α:: Impact on the epidemiology of the HIV-1 pandemic [J].

Gonzalez, E ;

Dhanda, R ;

Bamshad, M ;

Mummidi, S ;

Geevarghese, R ;

Catano, G ;

Anderson, SA ;

Walter, EA ;

Stephan, KT ;

Hammer, MF ;

Mangano, A ;

Sen, L ;

Clark, RA ;

Ahuja, SS ;

Dolan, MJ ;

Ahuja, SK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (09) :5199-5204

[40] Differential narrow focusing of immunodominant human immunodeficiency virus Gag-specific cytotoxic T-lymphocyte responses in infected African and Caucasoid adults and children [J].

Goulder, PJR ;

Brander, C ;

Annamalai, K ;

Mngqundaniso, N ;

Govender, U ;

Tang, Y ;

He, S ;

Hartman, KE ;

O'Callaghan, CA ;

Ogg, GS ;

Altfeld, MA ;

Rosenberg, ES ;

Cao, H ;

Kalams, SA ;

Hammond, M ;

Bunce, M ;

Pelton, SI ;

Burchett, SA ;

McIntosh, K ;

Coovadia, HM ;

Walker, BD .

JOURNAL OF VIROLOGY, 2000, 74 (12) :5679-5690

← 1 2 3 4 5 6 7 8 9 10 →