Improving the evaluation of new cancer treatments: challenges and opportunities

被引：122

作者：

Rothenberg, ML ^{[1
]}

Carbone, DR ^{[1
]}

Johnson, DH ^{[1
]}

机构：

[1] Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1047

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There are, at present, ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. Many of the new classes of agents, however, are predicted to work in only small subpopulations of patients, target unconventional aspects of tumour development and interact with other agents in an unpredictable manner. How can clinical trials be re-designed to accommodate the new features of targeted anticancer drugs?.

引用

页码：303 / 309

页数：7

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