Vaccine-Acquired Rotavirus in Infants with Severe Combined Immunodeficiency

被引：147

作者：

Patel, Niraj C. ^{[1
,7
]}

Hertel, Paula M. ^{[2
]}

Estes, Mary K. ^{[3
]}

de la Morena, Maite ^{[4
]}

Petru, Ann M. ^{[8
]}

Noroski, Lenora M. ^{[1
]}

Revell, Paula A. ^{[5
]}

Hanson, I. Celine ^{[1
]}

Paul, Mary E. ^{[1
]}

Rosenblatt, Howard M. ^{[6
]}

Abramson, Stuart L. ^{[1
]}

机构：

[1] Texas Childrens Hosp, Baylor Coll Med, Sect Allergy & Immunol, Dept Pediat, Houston, TX 77030 USA

[2] Texas Childrens Hosp, Baylor Coll Med, Gastroenterol Sect, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[4] Univ Texas SW, Dept Pediat, Dallas, TX USA

[5] Univ Texas SW, Dept Pathol, Dallas, TX USA

[6] Dell Childrens Med Ctr Cent Texas, Austin, TX USA

[7] Levine Childrens Hosp, Carolinas Med Ctr, Dept Pediat, Charlotte, NC USA

[8] Childrens Hosp & Res Ctr, Oakland, CA USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 362卷 / 04期

基金：

美国国家卫生研究院;

关键词：

DISSEMINATED BCG INFECTION; VIRAL GASTROENTERITIS; CHILDREN; VIREMIA; RISK; WC3;

D O I：

10.1056/NEJMoa0904485

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients.

引用

页码：314 / 319

页数：6

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