Evolution of function in (β/α)8-barrel enzymes

被引：120

作者：

Gerlt, JA

Raushel, FM

机构：

[1] Univ Illinois, Dept Biochem & Chem, Urbana, IL 61801 USA

[2] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(03)00019-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The (beta/alpha)(8)-barrel is the most common fold in structurally characterized enzymes. Whether the functionally diverse enzymes that share this fold are the products of either divergent or convergent evolution (or both) is an unresolved question that will probably be answered as the sequence databases continue to expand. Recent work has examined natural, designed, and directed evolution of function in several superfamilies of (beta/alpha)(8)-barrel containing enzymes.

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页码：252 / 264

页数：13

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