Berberine inhibits adipogenesis in high-fat diet-induced obesity mice

被引：99

作者：

Hu, Yueshan ^{[1
]}

Davies, Gareth E. ^{[1
,2
,3
]}

机构：

[1] S Dakota State Univ, Dept Pharmaceut Sci, Coll Pharm, Brookings, SD 57007 USA

[2] Avera Behav Hlth Ctr, Avera Inst Human Behav Genet, Sioux Falls, SD 57108 USA

[3] Univ S Dakota, Sanford Sch Med, Dept Psychiat, Sioux Falls, SD 57108 USA

来源：

FITOTERAPIA | 2010年 / 81卷 / 05期

关键词：

Berberine; Adipogenesis; Fat diet mice; PPAR gamma; C/EBP alpha; GATA; ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE; 3T3-L1; ADIPOCYTES; TRANSCRIPTION FACTORS; DIFFERENTIATION; MECHANISM; GAMMA; METABOLISM; IMPACT; EVODIAMINE;

D O I：

10.1016/j.fitote.2009.10.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Our previous studies illustrated that berberine inhibited adipogenesis in murine-derived 3T3-L1 preadipocytes and human white preadipocytes. In this study, the effects of berberine on the adipogenesis of high-fat diet-induced obesity (FD) or normal diet (ND) mice and possible transcriptional impact are investigated. The results demonstrated that in FD mice, berberine reduced mouse weight gain and food intake and serum glucose, triglyceride, and total cholesterol levels accompanied with a down-regulation of PPAR gamma expression and an up-regulation of GATA-3 expression. Berberine had no adverse effects on ND mice. These encouraging findings suggest that berberine has excellent pharmacological potential to prevent obesity. Published by Elsevier B.V.

引用

页码：358 / 366

页数：9

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