Tetraspanin proteins as organisers of membrane microdomains and signalling complexes

被引：130

作者：

Yunta, M ^{[1
]}

Lazo, PA ^{[1
]}

机构：

[1] Univ Salamanca, Inst Biol Mol & Celular Canc, Ctr Invest Canc, Consejo Spuer Invest Cientif, E-37007 Salamanca, Spain

来源：

CELLULAR SIGNALLING | 2003年 / 15卷 / 06期

关键词：

tetraspanin; microdomain; signalling complexes;

D O I：

10.1016/S0898-6568(02)00147-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tetraspanins are a group of hydrophobic proteins with four transmembrane domains and two extracellular loops, both with conserved residues. Some tetraspanins are cell specific and others are very ubiquitous. Tetraspanins interact with very different types of proteins such as integrins, membrane receptors, as well as intracellular signalling molecules. Tetraspanins can interact with other tetraspanins to form a larger complex, whose core is formed by six tetraspanins, surrounded several tetraspanin-associated proteins. These complexes can further aggregate and behave as a membrane microdomain. The great heterogeneity in their composition and the dynamics of tetraspanin complexes confers great flexibility on these proteins to participate in many different biological roles. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：559 / 564

页数：6

共 46 条

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