Enantioselective synthesis of the tricyclic core of (-)-FR901483

被引：22

作者：

Asari, Asnuzilawati ^{[1
]}

Angelov, Plamen ^{[1
]}

Auty, James M. ^{[1
]}

Hayes, Christopher J. ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 14期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/j.tetlet.2007.01.171

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective synthesis of the tricyclic core structure of the immunosuppressant natural product (-)-FR901483 has been achieved. A palladium-catalysed (Pd-2(dba)(3), Xantphos, KOPh) intramolecular enolate alkenylation reaction was used as the key ring forming step for the construction of the bicyclo-[3,3,1]-azanonane ring system. An alkylidene carbene 1,5-CH insertion reaction was used to construct the nitrogen-bearing stereocentre in the vinyl bromide cyclisation precursor. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2631 / 2634

页数：4

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