Experimental strategies for the genetic dissection of complex traits in animal models

被引：384

作者：

Darvasi, A ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

NATURE GENETICS | 1998年 / 18卷 / 01期

关键词：

D O I：

10.1038/ng0198-19

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Current success in detecting complex trait loci in general, and quantitative trait loci (QTLs) using model organisms in particular, has attracted major biological and biomedical interest. The potential ability to identify genes and their function provides opportunities for new diagnostics and treatments of complex genetic diseases. Despite the success in gene mapping, however, cloning of complex trait loci or QTLs is not straightforward. A major obstacle lies in achieving fine mapping resolution for the detected loci. Compared to the rapid development of sophisticated statistical and molecular tools, development and analysis of experimental designs for various stages in QTL mapping experiments have barely been considered. In this study, novel and existing experimental strategies for QTL analysis are presented and evaluated.

引用

页码：19 / 24

页数：6

共 64 条

[1] High-resolution mapping and isolation of a yeast artificial chromosome contig containing fw2.2: A major fruit weight quantitative trait locus in tomato [J].