State dependent properties of epileptic brain networks: Comparative graph-theoretical analyses of simultaneously recorded EEG and MEG

被引:163
作者
Horstmann, Marie-Therese [1 ,2 ,3 ]
Bialonski, Stephan [1 ,2 ,3 ]
Noennig, Nina [4 ]
Mai, Heinke [4 ]
Prusseit, Jens [1 ,2 ]
Wellmer, Joerg [1 ]
Hinrichs, Hermann [4 ]
Lehnertz, Klaus [1 ,2 ,3 ]
机构
[1] Univ Bonn, Dept Epileptol, D-53105 Bonn, Germany
[2] Univ Bonn, Helmholtz Inst Radiat & Nucl Phys, D-53115 Bonn, Germany
[3] Univ Bonn, Interdisciplinary Ctr Complex Syst, D-53117 Bonn, Germany
[4] Univ Magdeburg, Dept Neurol, D-39120 Magdeburg, Germany
关键词
Functional networks; Epilepsy; EEG; MEG; Interdependence; Behavioral state; Network reorganization; Graph theory; SMALL-WORLD NETWORKS; MULTI CHANNEL EEG; FUNCTIONAL CONNECTIVITY; PHASE SYNCHRONIZATION; COMPLEX NETWORKS; NEURAL NETWORKS; DYNAMICS; EPILEPTOGENESIS; COHERENCE; TOPOLOGY;
D O I
10.1016/j.clinph.2009.10.013
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To investigate whether functional brain networks of epilepsy patients treated with antiepileptic medication differ from networks of healthy controls even during the seizure-free interval. Methods: We applied different rules to construct binary and weighted networks from EEG and MEG data recorded under a resting-state eyes-open and eyes-closed condition from 21 epilepsy patients and 23 healthy controls. The average shortest path length and the clustering coefficient served as global statistical network characteristics. Results: Independent on the behavioral condition, epileptic brains exhibited a more regular functional network structure. Similarly, the eyes-closed condition was characterized by a more regular functional network structure in both groups. The amount of network reorganization due to behavioral state changes was similar in both groups. Consistent findings could be achieved for networks derived from EEG but hardly from MEG recordings, and network construction rules had a rather strong impact on our findings. Conclusions: Despite the locality of the investigated processes epileptic brain networks differ in their global characteristics from non-epileptic brain networks. Further methodological developments are necessary to improve the characterization of disturbed and normal functional networks. Significance: An increased regularity and a diminished modulation capability appear characteristic of epileptic brain networks. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:172 / 185
页数:14
相关论文
共 91 条
[51]   Molecular and diffusion tensor imaging of epileptic networks [J].
Luat, Aimee F. ;
Chugani, Harry T. .
EPILEPSIA, 2008, 49 :15-22
[52]   Detection of topological patterns in complex networks: correlation profile of the internet [J].
Maslov, S ;
Sneppen, M ;
Zaliznyak, A .
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 2004, 333 :529-540
[53]   Using graph theoretical analysis of multi channel EEG to evaluate the neural efficiency hypothesis [J].
Micheloyannis, Sifis ;
Pachou, Ellie ;
Stam, Cornelis J. ;
Vourkas, Michael ;
Erimaki, Sophia ;
Tsirka, Vasso .
NEUROSCIENCE LETTERS, 2006, 402 (03) :273-277
[54]   Epileptogenic neocortical networks are revealed by abnormal temporal dynamics in seizure-free subdural EEG [J].
Monto, Simo ;
Vanhatalo, Sampsa ;
Holmes, Mark D. ;
Palva, J. Matias .
CEREBRAL CORTEX, 2007, 17 (06) :1386-1393
[55]   Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures [J].
Morgan, Robert J. ;
Soltesz, Ivan .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (16) :6179-6184
[56]   Mean phase coherence as a measure for phase synchronization and its application to the EEG of epilepsy patients [J].
Mormann, F ;
Lehnertz, K ;
David, P ;
Elger, CE .
PHYSICA D, 2000, 144 (3-4) :358-369
[57]   On the predictability of epileptic seizures [J].
Mormann, F ;
Kreuz, T ;
Rieke, C ;
Andrzejak, RG ;
Kraskov, A ;
David, P ;
Elger, CE ;
Lehnertz, K .
CLINICAL NEUROPHYSIOLOGY, 2005, 116 (03) :569-587
[58]   Epilepsy in small-world networks [J].
Netoff, TI ;
Clewley, R ;
Arno, S ;
Keck, T ;
White, JA .
JOURNAL OF NEUROSCIENCE, 2004, 24 (37) :8075-8083
[59]   EEG coherency .1. Statistics, reference electrode, volume conduction, Laplacians, cortical imaging, and interpretation at multiple scales [J].
Nunez, PL ;
Srinivasan, R ;
Westdorp, AF ;
Wijesinghe, RS ;
Tucker, DM ;
Silberstein, RB ;
Cadusch, PJ .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1997, 103 (05) :499-515
[60]   THE EEG AS POTENTIAL MAPPING - THE VALUE OF THE AVERAGE MONOPOLAR REFERENCE [J].
OFFNER, FF .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1950, 2 (02) :213-214