Genetic associations: false or true?

被引：222

作者：

Ioannidis, JPA ^{[1
]}

机构：

[1] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Clin & Mol Epidemiol Unit, GR-45110 Ioannina, Greece

[2] Fdn Res & Technol Hellas, Biomed Res Inst, Ioannina, Greece

来源：

TRENDS IN MOLECULAR MEDICINE | 2003年 / 9卷 / 04期

关键词：

D O I：

10.1016/S1471-4914(03)00030-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic association studies for multigenetic diseases are like fishing for the truth in a sea of trillions of candidate analyses. Red herrings are unavoidably common, and bias might cause serious misconceptions. However, a sizeable proportion of identified genetic associations are probably true. Meta-analysis, a rigorous, comprehensive, quantitative synthesis of all the available data, might help us to separate the true from the false.

引用

页码：135 / 138

页数：4

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