Synthesis of analogues of nucleotides with all-carbon backbones:: synthesis of N-protected C-linked dinucleotides

被引：3

作者：

Butterfield, K ^{[1
]}

Thomas, EJ ^{[1
]}

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 04期

关键词：

D O I：

10.1039/a706857c

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Oxidative cleavage of the protected 3'-propenyl-3'-deoxythymidine 28 using osmium tetraoxide and sodium periodate gives the aldehyde 29 which is converted via the acid 30 and imidazolide 31 into the stabilized ylide 32. This is condensed with the thymidine derived aldehyde hydrate 24 to give the dinucleotide analogue 34. Hydrogenation and desilylation give the saturated dinucleotide analogues 36 and 37.

引用

页码：737 / 745

页数：9

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