OLIGODEOXYNUCLEOTIDES CONTAINING 3'-ALLYLETHER, 3'-ALLYLSULFIDE AND THEIR SATURATED DERIVATIVES AS PHOSPHATE MIMICS

被引：12

作者：

CAO, XD

MATTEUCCI, MD

机构：

[1] Gilead Sciences Inc., Foster City, CA 94404 German,

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 15期

关键词：

D O I：

10.1016/0040-4039(94)85210-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel thymidine-thymidine dimers containing 3'-allylether, 9'-allylsulfide connections and their saturated derivatives have been prepared and incorporated into oligodeoxynucleotides (ODNs). The 3'-allylether analog results in only a modest destablization of double helix formation with a complementary ssRNA relative to the phosphodiester linkage. This fact coupled with its facile synthesis may point to an application of this linkage in oligonucleotide-based therapeutics.

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页码：2325 / 2328

页数：4

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