A SULFIDE-LINKED OLIGONUCLEOTIDE ANALOG WITH SELECTIVE HYBRIDIZATION PROPERTIES

被引：33

作者：

MENG, B ^{[1
]}

KAWAI, SH ^{[1
]}

WANG, DG ^{[1
]}

JUST, G ^{[1
]}

GIANNARIS, PA ^{[1
]}

DAMHA, MJ ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT CHEM,801 SHERBROOKE ST W,MONTREAL H3A 2K6,QUEBEC,CANADA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 05期

关键词：

D O I：

10.1002/anie.199307291

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

RNA and DNA sequences can be distinguished efficiently with a modified oligonucleotide incorporating nonhydrolyzable sulfide linkages. A dodecamer containing three thio-ether-linked riboT-T dimers 1 is easily prepared by standard solid-phase methods and binds cooperatively to complementary RNA but not to DNA. Oligonucleotides of this type should be of use in antisense technology.

引用

页码：729 / 731

页数：3

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