A SULFIDE-LINKED OLIGONUCLEOTIDE ANALOG WITH SELECTIVE HYBRIDIZATION PROPERTIES

被引：33

作者：

MENG, B ^{[1
]}

KAWAI, SH ^{[1
]}

WANG, DG ^{[1
]}

JUST, G ^{[1
]}

GIANNARIS, PA ^{[1
]}

DAMHA, MJ ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT CHEM,801 SHERBROOKE ST W,MONTREAL H3A 2K6,QUEBEC,CANADA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 05期

关键词：

D O I：

10.1002/anie.199307291

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

RNA and DNA sequences can be distinguished efficiently with a modified oligonucleotide incorporating nonhydrolyzable sulfide linkages. A dodecamer containing three thio-ether-linked riboT-T dimers 1 is easily prepared by standard solid-phase methods and binds cooperatively to complementary RNA but not to DNA. Oligonucleotides of this type should be of use in antisense technology.

引用

页码：729 / 731

页数：3

共 22 条

[11] BUILDING-BLOCKS FOR OLIGONUCLEOTIDE ANALOGS WITH DIMETHYLENE SULFIDE, SULFOXIDE, AND SULFONE GROUPS REPLACING PHOSPHODIESTER LINKAGES [J].

HUANG, Z ;

SCHNEIDER, KC ;

BENNER, SA .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (12) :3869-3882

[12] OLIGONUCLEOTIDES WITH A NUCLEASE-RESISTANT SULFUR-BASED LINKAGE [J].

HUIE, EM ;

KIRSHENBAUM, MR ;

TRAINOR, GL .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (17) :4569-4570

[13]

KAWAI SH, IN PRESS CARBOHYDR R, V21

[14] HYBRIDIZATION PROPERTIES OF A DEOXYOLIGONUCLEOTIDE CONTAINING 4 FORMACETAL LINKAGES [J].

MATTEUCCI, M .

NUCLEOSIDES & NUCLEOTIDES, 1991, 10 (1-3) :231-234

[15]

MEIER C, 1992, ANGEW CHEM INT EDIT, V31, P1008, DOI 10.1002/anie.199210081

[16]

MEIER C, 1992, ANGEW CHEM, V104, P1039

[17] SYNTHESIS OF NUCLEOSIDE SULFONATES AND SULFONES [J].

MUSICKI, B ;

WIDLANSKI, TS .

TETRAHEDRON LETTERS, 1991, 32 (10) :1267-1270

[18]

SAENGER W, 1988, PRINCIPLES NUCLEIC A, pCH9

[19] UNCHARGED STEREOREGULAR NUCLEIC-ACID ANALOGS .2. MORPHOLINO NUCLEOSIDE OLIGOMERS WITH CARBAMATE INTERNUCLEOSIDE LINKAGES [J].

STIRCHAK, EP ;

SUMMERTON, JE ;

WELLER, DD .

NUCLEIC ACIDS RESEARCH, 1989, 17 (15) :6129-6141

[20] UNCHARGED STEREOREGULAR NUCLEIC-ACID ANALOGS .1. SYNTHESIS OF A CYTOSINE-CONTAINING OLIGOMER WITH CARBAMATE INTERNUCLEOSIDE LINKAGES [J].

STIRCHAK, EP ;

SUMMERTON, JE ;

WELLER, DD .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (19) :4202-4206

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