The general view that mRNA does not contain inosine has been challenged by the discovery of adenosine deaminases that act on RNA (ADARs). Although inosine monophosphate (IMP) cannot he detected in crude preparations of nucleotides derived from poly(A)(+) RNA, here we show it is readily detectable and quantifiable once it is purified away from the Watson-Crick nucleotides. We report that IMP is present in mRNA at tissue-specific levels that correlate with the levels of ADAR mRNA expression. The amount of IMP present in poly(A)(+) RNA isolated from various mammalian tissues suggests adenosine deamination may play an important role in regulating gene expression, particularly in brain, where we estimate one IMP is present for every 17 000 ribonucleotides.
机构:
STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS
BENNE, R
;
VANDENBURG, J
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STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS
VANDENBURG, J
;
BRAKENHOFF, JPJ
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STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS
BRAKENHOFF, JPJ
;
SLOOF, P
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STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS
SLOOF, P
;
VANBOOM, JH
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STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS
VANBOOM, JH
;
TROMP, MC
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机构:
STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS
机构:
STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS
BENNE, R
;
VANDENBURG, J
论文数: 0引用数: 0
h-index: 0
机构:
STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS
VANDENBURG, J
;
BRAKENHOFF, JPJ
论文数: 0引用数: 0
h-index: 0
机构:
STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS
BRAKENHOFF, JPJ
;
SLOOF, P
论文数: 0引用数: 0
h-index: 0
机构:
STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS
SLOOF, P
;
VANBOOM, JH
论文数: 0引用数: 0
h-index: 0
机构:
STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS
VANBOOM, JH
;
TROMP, MC
论文数: 0引用数: 0
h-index: 0
机构:
STATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDSSTATE UNIV LEIDEN,GORLAEUS LABS,DEPT ORGAN CHEM,2300 RA LEIDEN,NETHERLANDS