Practical highly enantioselective synthesis of terminal propargylamines.: An expeditious synthesis of (S)-(+)-coniine

被引：112

作者：

Gommermann, N ^{[1
]}

Knochel, P ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 20期

关键词：

D O I：

10.1039/b409951f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The one-pot three-component addition reaction of trimethylsilylacetylene, aldehydes and dibenzylamine provides in the presence of CuBr/Quinap as catalyst, various enantiomerically enriched propargylamines in good yields (up to 99%) and excellent enantiomeric excess (up to 98% ee) which can be used as a key intermediate in the synthesis of the alkaloid (S)-(+)-coniine.

引用

页码：2324 / 2325

页数：2

共 40 条

[1] Electron and proton reservoir complexes: Thermodynamic basis for C-H activation and applications in redox and dendrimer chemistry [J].