Potential antitumor promoting diterpenoids from the stem bark of Thuja standishii

被引：39

作者：

Iwamoto, M

Minami, T

Tokuda, H

Ohtsu, H

Tanaka, R

机构：

[1] Osaka Univ Pharmaceut Sci, Dept Med Chem, Takatsuki, Osaka 5691094, Japan

[2] Kyoto Prefectural Univ Med, Dept Biochem, Kyoto 602, Japan

来源：

PLANTA MEDICA | 2003年 / 69卷 / 01期

关键词：

D O I：

10.1055/s-2003-37037

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six diterpenes, including one new natural product, were isolated from a CHCl3 extract of the stem bark of Thuja standishii. The new compound has been characterized as 15-oxolabda-8(17),13Z-dien-19-oic acid. The known compounds were identified as ferruginol (2), sugiol (3), isocupressic acid (4), sandaracopimaric acid (5) and 15-oxolabda-8(17),13E-dien-19-oic acid (6). Compounds 2 - 5 and the derivatives 4a and 4b were tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA). Compounds 2, 3, 4 and 5 showed strong inhibitory effect on EBV-EA induction (100% inhibition at 1000 mol ratio/TPA).

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页码：69 / 72

页数：4

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