Regulation of BMP/Dpp signaling during embryonic development

被引:44
作者
Nakayama, T [1 ]
Cui, Y [1 ]
Christian, JL [1 ]
机构
[1] Oregon Hlth Sci Univ, Sch Med, Dept Cell & Dev Biol, Portland, OR 97201 USA
关键词
bone morphogenetic protein (BMP); Smad; decapentaplegic (Dpp); embryo; signal transduction;
D O I
10.1007/PL00000736
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bone morphogenetic protein-4 (BMP-4) and its Drosophila ortholog, decapentaplegic (Dpp), are multifunctional developmental regulators. Both gain-of-function and loss-of-function studies demonstrate that the biological activity and signaling range of these morphogens must be strictly regulated to ensure normal embryonic patterning. BMP-4 and Dpp are produced from inactive precursors that are proteolytically cleaved, following which the active ligand is secreted into the extracellular space. Binding of BMP-4 or Dpp to its cognate receptor leads to phosphorylation of intracellular signal-transducing Smad proteins that then form hetero-oligomers, translocate to the nucleus and modulate transcription of target genes. Recent studies have shown that the BMP signal transduction cascade can be modulated at every step of this process.
引用
收藏
页码:943 / 956
页数:14
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