MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

被引：79

作者：

Kalafatovic, Daniela ^{[1
]}

Nobis, Max ^{[2
]}

Javid, Nadeem ^{[1
]}

Frederix, Pim W. J. M. ^{[1
]}

Anderson, Kurt I. ^{[2
]}

Saunders, Brian R. ^{[3
]}

Ulijn, Rein V. ^{[1
,4
,5
]}

机构：

[1] Univ Strathclyde, Dept Pure & Appl Chem, West CHEM, Glasgow G1 1XL, Lanark, Scotland

[2] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

[3] Univ Manchester, Sch Mat, Manchester M1 7HS, Lancs, England

[4] CUNY, ASRC, New York, NY 10031 USA

[5] CUNY, Hunter Coll, Dept Chem & Biochem, New York, NY 10065 USA

来源：

BIOMATERIALS SCIENCE | 2015年 / 3卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

PEPTIDE AMPHIPHILES; SMALL MOLECULES; MATRIX METALLOPROTEINASES; CLEAVAGE SITES; HYDROGELS; CANCER; SUBSTRATE; DESIGN; CELLS; NANOSTRUCTURES;

D O I：

10.1039/c4bm00297k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

引用

页码：246 / 249

页数：4

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