A bacterial RNA that functions as both a tRNA and an mRNA

被引：116

作者：

Muto, A ^{[1
]}

Ushida, C ^{[1
]}

Himeno, H ^{[1
]}

机构：

[1] Hirosaki Univ, Fac Sci, Dept Biol, Hirosaki, Aomori 036, Japan

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 01期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0968-0004(97)01159-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial tmRNA (transfer-messenger RNA, also known as 10Sa RNA) contains a tRNA-like structure in the 5'- and 3'-end sequences and an internal reading frame encoding a 'tag' peptide. The dual function of this molecule as both a tRNA and an mRNA facilitates a trans-translation reaction, in which a ribosome can switch between translation of a truncated mRNA and the tmRNA's tag sequence. The result is a chimeric protein with the tag peptide attached to the C terminus of the truncated peptide.

引用

页码：25 / 29

页数：5

共 36 条

[21] CHANGING THE IDENTITY OF A TRANSFER-RNA BY INTRODUCING A G-U WOBBLE PAIR NEAR THE 3' ACCEPTOR END
MCCLAIN, WH
FOSS, K
[J]. SCIENCE, 1988, 240 (4853) : 793 - 796
[22] Structure and function of 10Sa RNA: Trans-translation system
Muto, A
Sato, M
Tadaki, T
Fukushima, M
Ushida, C
Himeno, H
[J]. BIOCHIMIE, 1996, 78 (11-12) : 985 - 991
[23] THE ORGANIZATION AND EVOLUTION OF TRANSFER-RNA GENES IN MYCOPLASMA-CAPRICOLUM
MUTO, A
ANDACHI, Y
YUZAWA, H
YAMAO, F
OSAWA, S
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (17) : 5037 - 5043
[24] CRYSTAL-STRUCTURE OF THE TERNARY COMPLEX OF PHE-TRNA(PHE), EF-TU, AND A GTP ANALOG
NISSEN, P
KJELDGAARD, M
THIRUP, S
POLEKHINA, G
RESHETNIKOVA, L
CLARK, BFC
NYBORG, J
[J]. SCIENCE, 1995, 270 (5241) : 1464 - 1472
[25] OFENGAND J, 1993, TRANSLATIONAL APPARATUS, P489
[26] 10SA RNA, A SMALL STABLE RNA OF ESCHERICHIA-COLI, IS FUNCTIONAL
OH, BK
APIRION, D
[J]. MOLECULAR & GENERAL GENETICS, 1991, 229 (01): : 52 - 56
[27] RAY BK, 1979, MOL GEN GENET, V174, P25, DOI 10.1007/BF00433301
[28] ROLE FOR 10SA RNA IN THE GROWTH OF LAMBDA-P22 HYBRID PHAGE
RETALLACK, DM
JOHNSON, LL
FRIEDMAN, DI
[J]. JOURNAL OF BACTERIOLOGY, 1994, 176 (07) : 2082 - 2089
[29] A ROLE FOR A SMALL STABLE RNA IN MODULATING THE ACTIVITY OF DNA-BINDING PROTEINS
RETALLACK, DM
FRIEDMAN, DI
[J]. CELL, 1995, 83 (02) : 227 - 235
[30] SHI JP, 1991, J BIOL CHEM, V266, P2705

← 1 2 3 4 →