Methylation of (2-methylethanethiol-bis-3,5-dimethylpyrazolyl)methane zinc complexes and coordination of the resulting thioether: relevance to zinc-containing alkyl transfer enzymes

被引：56

作者：

Hammes, BS ^{[1
]}

Carrano, CJ ^{[1
]}

机构：

[1] SW Texas State Univ, Dept Chem & Biochem, San Marcos, TX 78666 USA

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 17期

关键词：

D O I：

10.1039/b004338i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Methylation of the coordinated thiolate in pseudotetrahedral Zn complexes of the form [(L3S)ZnX] by a variety of alkylating agents appears to occur via a nondissociative route and the resulting thioether can remain coordinated to the metal center as it does in zinc dependent alkyl transfer enzymes such as the DNA repair protein, Ada, from Escherichia coli.

引用

页码：1635 / 1636

页数：2

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