Yeast apoptosis -: From genes to pathways

被引：62

作者：

Froehlich, Kai-Uwe ^{[1
]}

Fussi, Heike ^{[1
]}

Ruckenstuhl, Christoph ^{[1
]}

机构：

[1] Graz Univ, IMB, Graz, Austria

来源：

SEMINARS IN CANCER BIOLOGY | 2007年 / 17卷 / 02期

关键词：

yeast; apoptosis; model organism; stress; ageing; PROGRAMMED CELL-DEATH; ACID INDUCES APOPTOSIS; SACCHAROMYCES-CEREVISIAE; OXIDATIVE-STRESS; SCHIZOSACCHAROMYCES-POMBE; REGULATES APOPTOSIS; CYTOCHROME-C; UTH1; GENE; PROTEIN; CYCLE;

D O I：

10.1016/j.semcancer.2006.11.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Yeast are eukaryotic unicellular organisms that are easy to cultivate and offer a wide spectrum of genetic and cytological tools for research. Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe have successfully been used as models for human cell division cycle. Stress conditions, cellular ageing, failed mating, certain mutations or heterologous expression of proapoptotic genes induce yeast cell death with the characteristic markers of apoptosis. Several crucial regulators of apoptosis are conserved between metazoans and yeast. This simple model organism offers the possibility to identify conserved and new components of the apoptotic machinery and to elucidate the regulatory pathways beyond. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：112 / 121

页数：10

相关论文

共 106 条

[1] Autophagy in yeast: Mechanistic insights and physiological function [J].

Abeliovich, H ;

Klionsky, DJ .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2001, 65 (03) :463-+

[2] Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae [J].

Ahn, SH ;

Cheung, WL ;

Hsu, JY ;

Diaz, RL ;

Smith, MM ;

Allis, CD .

CELL, 2005, 120 (01) :25-36

[3] Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10 [J].

Ahn, Sung-Hee ;

Diaz, Robert L. ;

Grunstein, Michael ;

Allis, C. David .

MOLECULAR CELL, 2006, 24 (02) :211-220

[4] Aspirin commits yeast cells to apoptosis depending on carbon source [J].

Balzan, R ;

Sapienza, K ;

Galea, DR ;

Vassallo, N ;

Frey, H ;

Bannister, WH .

MICROBIOLOGY-SGM, 2004, 150 :109-115

[5] Involvement of the Saccharomyces cerevisiae UTH1 gene in the oxidative-stress response [J].

Bandara, PDS ;

Flattery-O'Brien, JA ;

Grant, CM ;

Dawes, IW .

CURRENT GENETICS, 1998, 34 (04) :259-268

[6] Involvement of the yeast metacaspase Yca1 in ubp10Δ-programmed cell death [J].

Bettiga, M ;

Calzari, L ;

Orlandi, I ;

Alberghina, L ;

Vai, M .

FEMS YEAST RESEARCH, 2004, 5 (02) :141-147

[7] Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast [J].

Blanchard, F ;

Rusiniak, ME ;

Sharma, K ;

Sun, XL ;

Todorov, I ;

Castellano, MM ;

Gutierrez, C ;

Baumann, H ;

Burhans, WC .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (05) :1536-1549

[8] Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast [J].

Braun, Ralf J. ;

Zischka, Hans ;

Madeo, Frank ;

Eisenberg, Tobias ;

Wissing, Silke ;

Buettner, Sabrina ;

Engelhardt, Silvia M. ;

Bueringer, Dietmute ;

Ueffing, Marius .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (35) :25757-25767

[9] Apoptosis-like yeast cell death in response to DNA damage and replication defects [J].

Burhans, WC ;

Weinberger, M ;

Marchetti, MA ;

Ramachandran, L ;

D'Urso, G ;

Huberman, JA .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2003, 532 (1-2) :227-243

[10] Uth1p:: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death [J].

Camougrand, N ;

Kissová, I ;

Velours, G ;

Manon, S .

FEMS YEAST RESEARCH, 2004, 5 (02) :133-140

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