Weight change in later life and risk of death amongst the elderly: the European Prospective Investigation into Cancer and Nutrition-Elderly Network on Ageing and Health study

被引：48

作者：

Bamia, C. ^{[1
]}

Halkjaer, J. ^{[2
]}

Lagiou, P. ^{[1
,3
]}

Trichopoulos, D. ^{[3
,4
,5
]}

Tjonneland, A. ^{[2
]}

Berentzen, T. L. ^{[6
]}

Overvad, K. ^{[7
,8
]}

Clavel-Chapelon, F. ^{[9
]}

Boutron-Ruault, M. -C. ^{[9
]}

Rohrmann, S. ^{[10
]}

Linseisen, J. ^{[10
,11
]}

Steffen, A. ^{[12
]}

Boeing, H. ^{[12
]}

May, A. M. ^{[13
]}

Peeters, P. H. ^{[13
,14
]}

Bueno-de-Mesquita, H. Bas ^{[15
]}

van den Berg, S. W. ^{[15
]}

Dorronsoro, M. ^{[16
]}

Barricarte, A. ^{[17
]}

Rodriguez Suarez, L. ^{[18
]}

Navarro, C. ^{[19
]}

Gonzalez, C. A. ^{[20
]}

Boffetta, P. ^{[21
]}

Pala, V. ^{[22
]}

Hallmans, G. ^{[23
]}

Trichopoulou, A. ^{[1
,5
]}

机构：

[1] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[2] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[3] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[4] Acad Athens, Bur Epidemiol Res, Athens, Greece

[5] Hellen Hlth Fdn, Athens, Greece

[6] Copenhagen Univ Hosp, Inst Prevent Med, Ctr Hlth & Soc, Copenhagen, Denmark

[7] Aarhus Univ, Inst Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[8] Aarhus Univ Hosp, Aalborg Hosp, Cardiovasc Res Ctr, Dept Cardiol, Aalborg, Denmark

[9] Univ Paris 11, Inst Gustave Roussy, INSERM, ERI 20,IFR 69, Paris, France

[10] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[11] Helmholtz Ctr Munich, Inst Epidemiol, Potsdam, Germany

[12] German Inst Human Nutr Potsdam Rehbrucke, Potsdam, Germany

[13] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[14] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England

[15] Natl Inst Publ Hlth & Environm RIVM, Ctr Nutr & Hlth, Bilthoven, Netherlands

[16] Gipuzkoa & Ciberesp, Dept Publ Hlth, San Sebastian, Spain

[17] Hlth Inst Navarra, Pamplona, Spain

[18] Hlth & Healthcare Serv Council, Asturias, Spain

[19] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[20] Catalan Inst Oncol, Unit Nutr Environm & Canc, Barcelona, Spain

[21] Int Agcy Res Canc, F-69372 Lyon, France

[22] Fdn IRCSS Ist Nazl Tumori, Dept Prevent & Predict Med, Nutr Epidemiol Unit, Milan, Italy

[23] Dept Prevent & Predict Med, Umea, Sweden

来源：

JOURNAL OF INTERNAL MEDICINE | 2010年 / 268卷 / 02期

关键词：

body mass index; mortality; obesity; weight gain; weight loss; BODY-MASS INDEX; CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; OLD-AGE; MIDDLE-AGE; FOLLOW-UP; PHYSICAL-ACTIVITY; FAT DISTRIBUTION; WOMEN; OVERWEIGHT;

D O I：

10.1111/j.1365-2796.2010.02219.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Later life weight change and mortality amongst elders. Design. Nested case-control study. Setting. Six countries from the European Investigation into Cancer and nutrition - Elderly, Network on Ageing and Health. Subjects. A total of 1712 deceased (cases) and 4942 alive (controls) were selected from 34 239 participants, >= 60 years at enrolment (1992-2000) who were followed-up until March 2007. Annual weight change was estimated as the weight difference from recruitment to the most distant from-date-of-death re-assessment, divided by the respective time. Outcome measures. Mortality in relation to weight change was examined using conditional logistic regression. Results. Weight loss > 1 kg year-1 was associated with statistically significant increased death risk (OR = 1.65; 95% CI: 1.41-1.92) compared to minimal weight change (+/- 1 kg year-1). Weight gain > 1 kg year-1 was also associated with increased risk of death (OR = 1.15; 95% CI: 0.98-1.37), but this was evident and statistically significant only amongst overweight/obese (OR = 1.55; 95% CI: 1.17-2.05). In analyses by time interval since weight re-assessment, the association of mortality with weight loss was stronger for the interval proximal (< 1 year) to death (OR = 3.10; 95% CI: 2.03-4.72). The association of mortality with weight gain was stronger at the interval of more than 3 years and statistically significant only amongst overweight/obese (OR = 1.58; 95% CI: 1.07-2.33). Similar patterns were observed regarding death from circulatory diseases and cancer. Conclusions. In elderly, stable body weight is a predictor of lower subsequent mortality. Weight loss is associated with increased mortality, particularly short-term, probably reflecting underlying nosology. Weight gain, especially amongst overweight/obese elders, is also associated with increased mortality, particularly longer term.

引用

页码：133 / 144

页数：12

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