Weight change in later life and risk of death amongst the elderly: the European Prospective Investigation into Cancer and Nutrition-Elderly Network on Ageing and Health study

被引:48
作者
Bamia, C. [1 ]
Halkjaer, J. [2 ]
Lagiou, P. [1 ,3 ]
Trichopoulos, D. [3 ,4 ,5 ]
Tjonneland, A. [2 ]
Berentzen, T. L. [6 ]
Overvad, K. [7 ,8 ]
Clavel-Chapelon, F. [9 ]
Boutron-Ruault, M. -C. [9 ]
Rohrmann, S. [10 ]
Linseisen, J. [10 ,11 ]
Steffen, A. [12 ]
Boeing, H. [12 ]
May, A. M. [13 ]
Peeters, P. H. [13 ,14 ]
Bueno-de-Mesquita, H. Bas [15 ]
van den Berg, S. W. [15 ]
Dorronsoro, M. [16 ]
Barricarte, A. [17 ]
Rodriguez Suarez, L. [18 ]
Navarro, C. [19 ]
Gonzalez, C. A. [20 ]
Boffetta, P. [21 ]
Pala, V. [22 ]
Hallmans, G. [23 ]
Trichopoulou, A. [1 ,5 ]
机构
[1] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece
[2] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark
[3] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[4] Acad Athens, Bur Epidemiol Res, Athens, Greece
[5] Hellen Hlth Fdn, Athens, Greece
[6] Copenhagen Univ Hosp, Inst Prevent Med, Ctr Hlth & Soc, Copenhagen, Denmark
[7] Aarhus Univ, Inst Publ Hlth, Dept Epidemiol, Aarhus, Denmark
[8] Aarhus Univ Hosp, Aalborg Hosp, Cardiovasc Res Ctr, Dept Cardiol, Aalborg, Denmark
[9] Univ Paris 11, Inst Gustave Roussy, INSERM, ERI 20,IFR 69, Paris, France
[10] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany
[11] Helmholtz Ctr Munich, Inst Epidemiol, Potsdam, Germany
[12] German Inst Human Nutr Potsdam Rehbrucke, Potsdam, Germany
[13] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
[14] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England
[15] Natl Inst Publ Hlth & Environm RIVM, Ctr Nutr & Hlth, Bilthoven, Netherlands
[16] Gipuzkoa & Ciberesp, Dept Publ Hlth, San Sebastian, Spain
[17] Hlth Inst Navarra, Pamplona, Spain
[18] Hlth & Healthcare Serv Council, Asturias, Spain
[19] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain
[20] Catalan Inst Oncol, Unit Nutr Environm & Canc, Barcelona, Spain
[21] Int Agcy Res Canc, F-69372 Lyon, France
[22] Fdn IRCSS Ist Nazl Tumori, Dept Prevent & Predict Med, Nutr Epidemiol Unit, Milan, Italy
[23] Dept Prevent & Predict Med, Umea, Sweden
关键词
body mass index; mortality; obesity; weight gain; weight loss; BODY-MASS INDEX; CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; OLD-AGE; MIDDLE-AGE; FOLLOW-UP; PHYSICAL-ACTIVITY; FAT DISTRIBUTION; WOMEN; OVERWEIGHT;
D O I
10.1111/j.1365-2796.2010.02219.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. Later life weight change and mortality amongst elders. Design. Nested case-control study. Setting. Six countries from the European Investigation into Cancer and nutrition - Elderly, Network on Ageing and Health. Subjects. A total of 1712 deceased (cases) and 4942 alive (controls) were selected from 34 239 participants, >= 60 years at enrolment (1992-2000) who were followed-up until March 2007. Annual weight change was estimated as the weight difference from recruitment to the most distant from-date-of-death re-assessment, divided by the respective time. Outcome measures. Mortality in relation to weight change was examined using conditional logistic regression. Results. Weight loss > 1 kg year-1 was associated with statistically significant increased death risk (OR = 1.65; 95% CI: 1.41-1.92) compared to minimal weight change (+/- 1 kg year-1). Weight gain > 1 kg year-1 was also associated with increased risk of death (OR = 1.15; 95% CI: 0.98-1.37), but this was evident and statistically significant only amongst overweight/obese (OR = 1.55; 95% CI: 1.17-2.05). In analyses by time interval since weight re-assessment, the association of mortality with weight loss was stronger for the interval proximal (< 1 year) to death (OR = 3.10; 95% CI: 2.03-4.72). The association of mortality with weight gain was stronger at the interval of more than 3 years and statistically significant only amongst overweight/obese (OR = 1.58; 95% CI: 1.07-2.33). Similar patterns were observed regarding death from circulatory diseases and cancer. Conclusions. In elderly, stable body weight is a predictor of lower subsequent mortality. Weight loss is associated with increased mortality, particularly short-term, probably reflecting underlying nosology. Weight gain, especially amongst overweight/obese elders, is also associated with increased mortality, particularly longer term.
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收藏
页码:133 / 144
页数:12
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