Effect of luteinizing hormone-releasing hormone on rat adrenocortical cells

被引：8

作者：

Andreis, PG ^{[1
]}

Neri, G ^{[1
]}

Nussdorfer, GG ^{[1
]}

机构：

[1] Univ Padua, Dept Anat, I-35121 Padua, Italy

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1997年 / 63卷 / 1-3期

关键词：

D O I：

10.1016/S0960-0760(97)00066-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of luteinizing hormone-releasing hormone (LH-RH) on the function of rat adrenal cortex were investigated by using dispersed zona glomerulosa (capsular) and zona fasciculata-reticularis (inner) cells. LH-RH increased basal (but not adrenocorticotropic hormone (ACTH)-stimulated) corticosterone secretion of inner cells, without affecting either aldosterone or corticosterone production by capsular cells. LH-RH markedly raised basal (but not ACTH-enhanced) cyclic-AMP release by inner cells. The corticosterone secretagogue action of LH-RH was abolished by the protein kinase A inhibitor H-89. The conclusion is drawn that LH-RH specifically stimulates adrenal glucocorticoid secretion in rats through the activation of the adenylate cyclase signaling pathway. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：17 / 19

页数：3

共 7 条

[1] ADRENAL LUTEINIZING-HORMONE RELEASING HORMONE RECEPTORS [J].