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Electron microscopy of functional ribosome complexes

被引：46
作者：
Frank, J [1 ]
机构：
[1] Wadsworth Ctr, Howard Hughes Med Inst, Hlth Res Inc, Albany, NY 12201 USA
[2] SUNY Albany, Dept Biomed Sci, Albany, NY 12201 USA
来源：
BIOPOLYMERS | 2003年 / 68卷 / 02期
关键词：
translation; tRNA; EF-G; three-dimensional reconstruction; molecular machines;
D O I：
10.1002/bip.10210
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cryoelectron microscopy has made a number of significant contributions to our understanding of the translation process. The method of single-particle reconstruction is particularly well suited for the study of the dynamics of ribosome-ligand interactions. This review,follows the events of the functional cycle and discusses the findings in the context provided by the recently published x-ray structures. (C) 2003 Wiley Periodicals, Inc.
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页码：223 / 233
页数：11
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