Invasive Haemophilus influenzae Disease in Utah Children: An 11-Year Population-Based Study in the Era of Conjugate Vaccine

被引:53
作者
Bender, Jeffrey M. [1 ]
Cox, Chad M.
Mottice, Susan [2 ]
She, Rosemary C. [3 ]
Korgenski, Kent [4 ]
Daly, Judy A. [4 ]
Pavia, Andrew T.
机构
[1] Univ Utah, Sch Med, Dept Pediat, Div Pediat Infect Dis, Salt Lake City, UT 84158 USA
[2] Utah Dept Hlth, Salt Lake City, UT 84116 USA
[3] ARUP Labs, Salt Lake City, UT USA
[4] Primary Childrens Med Ctr, Salt Lake City, UT 84103 USA
关键词
UNITED-STATES; BACTERIAL-MENINGITIS; SEROTYPE-A; EPIDEMIOLOGY; INFECTIONS; NAVAJO; IMPACT;
D O I
10.1086/651165
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. The incidence of invasive Haemophilus influenzae infection decreased dramatically since the introduction of the H. influenzae serotype b (Hib) conjugate vaccine. H. influenzae invasive disease continues to occur and cause significant morbidity and mortality in children aged < 5 years. We aimed to report the epidemiology and serotypes of invasive H. influenzae disease in children from Utah in the post-Hib vaccine era. Methods. We identified all cases of invasive H. influenzae disease, defined as H. influenzae isolated from a sterile site, during the period 1998-2008 among children aged < 18 years who were living in Utah. Results. We identified 91 cases of invasive H. influenzae disease in children. Children aged < 5 years accounted for 78 cases (86%). H. influenzae serotype a (Hia) was the most common serotype (22 cases), representing 28% of all cases of invasive disease among children aged < 5 years. The majority (15 cases [93%]) of Hib disease cases occurred among children aged < 5 years and accounted for 18% of all cases of H. influenzae invasive disease in this age group. The mean incidence of Hia disease increased from 0.8 cases per 100,000 child-years in 1998 to 2.6 cases per 100,000 child-years in 2008. The incidence of Hib disease among children aged < 5 years remained steady at 0.5 cases per 100,000 child-years. Bacteremia accounted for 61% of all cases of invasive disease. One-half (13 of 26) of cases of H. influenzae meningitis were due to Hia. Conclusions. H. influenzae continues to cause invasive disease in Utah children. Hia is the primary cause of the overall increased incidence of invasive H. influenzae disease and leads to disease similar to Hib. Isolated cases of Hib disease demonstrate a continued reservoir. The success of the Hib conjugate vaccine may therefore be vulnerable to vaccine shortages and refusal of vaccination.
引用
收藏
页码:E41 / E46
页数:6
相关论文
共 32 条
[1]   DECLINE OF CHILDHOOD HAEMOPHILUS-INFLUENZAE TYPE-B (HIB) DISEASE IN THE HIB VACCINE ERA [J].
ADAMS, WG ;
DEAVER, KA ;
COCHI, SL ;
PLIKAYTIS, BD ;
ZELL, ER ;
BROOME, CV ;
WENGER, JD .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 269 (02) :221-226
[2]   Invasive serotype a Haemophilus influenzae infections with a virulence genotype resembling Haemophilus influenzae type b:: Emerging pathogen in the vaccine era? [J].
Adderson, EE ;
Byington, CL ;
Spencer, L ;
Kimball, A ;
Hindiyeh, M ;
Carroll, K ;
Mottice, S ;
Korgenski, EK ;
Christenson, JC ;
Pavia, AT .
PEDIATRICS, 2001, 108 (01) :E18
[3]  
[Anonymous], 2009, STAT SURVEILLANCE IM
[4]   Haemophilus influenzae invasive disease in the United States, 1994-1995: Near disappearance of a vaccine-preventable childhood disease [J].
Bisgard, KM ;
Kao, A ;
Leake, J ;
Strebel, PM ;
Perkins, BA ;
Wharton, M .
EMERGING INFECTIOUS DISEASES, 1998, 4 (02) :229-237
[5]   Evaluation of methodology for serotyping invasive and nasopharyngeal isolates of Haemophilus influenzae in the ongoing surveillance in Brazil [J].
Bokermann, S ;
Zanella, RC ;
Lemos, APS ;
de Andrade, ALSS ;
Brandileone, MCD .
JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (12) :5546-5550
[6]   Epidemiology of Haemophilus influenzae serotype a, North American Arctic 2000-2005 [J].
Bruce, Michael G. ;
Deeks, Shelley L. ;
Zulz, Tammy ;
Navarro, Christine ;
Palacios, Carolina ;
Case, Cheryl ;
Hemsley, Colleen ;
Hennessy, Tom ;
Corriveau, Andre ;
Larke, Bryce ;
Sobel, Isaac ;
Lovgren, Marguerite ;
DeByle, Carolynn ;
Tsang, Raymond ;
Parkinson, Alan J. .
EMERGING INFECTIOUS DISEASES, 2008, 14 (01) :48-55
[7]   Septic arthritis due to Haemophilus influenzae serotype a in the post-vaccination era in Brazil [J].
Castro Cardoso de Almeida, Antonio Eugenio ;
Lima Schroeder, Leticia Ferreira ;
Santos Caldeira, Nathalia Goncalves ;
Matias da Silva, Nicea Magaly ;
Batista, Paulo Roberto ;
Gallo, Marta Pradel ;
de Filippis, Lvano .
JOURNAL OF MEDICAL MICROBIOLOGY, 2008, 57 (10) :1311-1312
[8]  
Centers for Disease Control and Prevention, 1998, MMWR-MORBID MORTAL W, V47, P993
[9]  
Coronado F., 2008, Morbidity and Mortality Weekly Report, V57, P1252
[10]  
COULEHAN JL, 1984, PUBLIC HEALTH REP, V99, P404