1,4-carbonylative addition of arylboronic acids to methyl vinyl ketone: a new synthetic tool for rapid furan and pyrrole synthesis

被引：25

作者：

Chochois, Helene ^{[1
]}

Sauthier, Mathieu ^{[1
]}

Maerten, Eddy ^{[1
]}

Castanet, Yves ^{[1
]}

Mortreux, Andr ^{[1
]}

机构：

[1] ENSCL, USTL, UMR 8181, CNRS,Unite Catalyse & Chim Solide, F-59652 Villeneuve Dascq, France

来源：

TETRAHEDRON | 2006年 / 62卷 / 50期

关键词：

D O I：

10.1016/j.tet.2006.09.035

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rhodium catalysed 1,4-carbonylative addition of arylboronic acids to methyl vinyl ketone under carbon monoxide pressure was studied. High yields of 1,4-diketones were obtained using a catalytic system formed from Rh(COD)(2)BF4 (COD= 1,5-cyclooctadiene) and triphenylphosphine even at very low catalyst loading (0.02 mol %). A short synthetic procedure combining this carbonylation reaction with a subsequent cyclisation step affords pyrroles or furans. (c) 2006 Elsevier Ltd. All rights, reserved.

引用

页码：11740 / 11746

页数：7

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