Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212

被引：77

作者：

Biava, M

Porretta, GC

Deidda, D

Pompei, R

Tafi, A

Manetti, F

机构：

[1] Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy

[2] Univ Cagliari, Fac Sci Matemat Fis Nat, Cattedra Microbiol Applicata, I-09124 Cagliari, Italy

[3] Univ Siena, Dipartimento Farm Chim Tecnol, I-53100 Siena, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0968-0896(02)00455-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the course of our investigations in the field of azole antimicrobial agents, we have identified BM 212, a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 1-10 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：515 / 520

页数：6

共 15 条

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