Spatiotemporal control of migration of single cells on a photoactivatable cell microarray

被引：91

作者：

Nakanishi, Jun

Kikuchi, Yukiko

Inoue, Satoshi

Yamaguchi, Kazuo

Takarada, Tohru

Maeda, Mizuo

机构：

[1] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

[2] Waseda Univ, Inst Biomed Engn, Consolidated Res Inst Adv Sci & Med Care, Shinjuku Ku, Tokyo 1620041, Japan

[3] Kanagawa Univ, Fac Sci, Dept Mat Sci, Hiratsuka, Kanagawa 2591293, Japan

[4] RIKEN, Bioengn Lab, Discovery Res Inst, Wako, Saitama 3510198, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 21期

关键词：

D O I：

10.1021/ja070294p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Spatiotemporal control of cell migration was achieved on a photoactivatable cell-culturing substrate. Single cells were micropatterned on the substrate and were induced to extend protrusions led by lamellipodia or filopodia alternatively by the subsequent formation of wide or narrow paths in their surroundings, respectively. By tracking the migration of single cells in a microarray format, we performed quantitative analysis of the migration rates of single cells.

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页码：6694 / +

页数：3

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