Synthesis and immunosuppressive activity of ruthenium complexes

被引：37

作者：

Bastos, CM ^{[1
]}

Gordon, KA ^{[1
]}

Ocain, TD ^{[1
]}

机构：

[1] Procept Inc, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(97)10205-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses and immunosuppressive activity of ruthenium complexes are described. One of the complexes (1a) was shown to be a potent inhibitor of human T-lymphocyte proliferation with an IC50 of 5 nM. The activity of these complexes compares favorably to the well known immunosuppressants Cyclosporin A and Rapamycin. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：147 / 150

页数：4

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